TSMS Scientific Glossary

Definition: Closeness of a measurement to an accepted or true value.

Definition: The substance or chemical species being measured.

Definition: An organic compound containing amino and carboxyl functionality that can serve as a peptide building block.

Definition: A quantitative determination of the amount or potency of an intended substance.

Definition: A secure chronological record of actions performed within an electronic system.

Definition: The detector response expected in the absence of an analyte peak.

Definition: Establishment of the relationship between instrument response and known reference values.

Definition: A plot of detector response against time or another separation coordinate.

Definition: A family of separation methods based on differential interactions with stationary and mobile phases.

Definition: Conversion of an amide-containing side chain, commonly asparagine or glutamine, to a related acidic form.

Definition: Mathematical reconstruction of neutral molecular mass from multiple observed charge states.

Definition: A covalent sulfur-sulfur linkage formed between cysteine residues.

Definition: A soft ionization technique that transfers ions from solution into the gas phase.

Definition: Combined measurement uncertainty multiplied by a coverage factor.

Definition: Controlled stress testing used to reveal degradation pathways and challenge analytical methods.

Definition: Chromatography in which mobile-phase composition changes during the run.

Definition: Chemical cleavage involving reaction with water.

Definition: High-performance liquid chromatography.

Definition: Evidence that the expected chemical entity is present.

Definition: A component other than the intended principal material.

Definition: Conversion of a neutral molecule into a charged species.

Definition: Chromatography performed with constant mobile-phase composition.

Definition: A molecule sharing a molecular formula with another molecule but differing in arrangement.

Definition: Liquid chromatography coupled to mass spectrometry.

Definition: The lowest amount that can be distinguished from background under defined conditions.